中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | VK466064 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064) is a rabbit polyclonal antibody detecting E1B-55K in ELISA, WB.
Highlights
|
||||||||
| 종 반응성 | Human adenovirus E serotype 41 (HAdV-41) | ||||||||
| 응용 분야 | ELISA, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant HAdV-41 E1B-55K (Lys98-Asp472). | ||||||||
| 타겟 | E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P10546 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | E1B 55 kDa protein (E1B-55K) is a ~52 kDa protein. Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. E1B-55K probably acts as the substrate-specific adapter of the SCF-like E3 ubiquitin ligase complex. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
