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| 카탈로그 번호 | VK734014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HAdV-7 Shutoff protein/L4 Polyclonal Antibody (VK734014) is a rabbit polyclonal antibody detecting Shutoff protein in ELISA, WB.
Highlights
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| 종 반응성 | Human adenovirus B serotype 7 (HAdV-7) | ||||||||
| 응용 분야 | ELISA, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant HAdV-7 Shutoff protein/L4 (Leu373-Arg537). | ||||||||
| 타겟 | Shutoff protein, 100 kDa protein, p100K, 100K-chaperone protein, L4-100K, Shutoff protein 100K, L4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q5EY60 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Shutoff protein (L4) is a ~92 kDa protein. Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers. | ||||||||
| 참고사항 | For research use only. |
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