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| 카탈로그 번호 | HY488014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HCK Polyclonal Antibody (HY488014) is a rabbit polyclonal antibody detecting HCK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Macaca fascicularis.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human HCK (Met22-Pro526). | ||||||||
| 타겟 | Hemopoietic cell kinase, Tyrosine-protein kinase HCK, p61Hck, p59-HCK/p60-HCK, Hematopoietic cell kinase, p59Hck, HCK | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P08631 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Tyrosine-protein kinase HCK is a ~59 kDa protein. Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. | ||||||||
| 참고사항 | For research use only. |
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