Anti-HDAC3 Polyclonal Antibody (HT281014)

Name: Anti-HDAC3 Polyclonal Antibody
Brand: abinScience
SKU: HT281014
Price: 168 USD
Availability: InStock

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100ug

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개요
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SDS

개요

카탈로그 번호

HT281014

설명

Anti-HDAC3 Polyclonal Antibody (HT281014) is a rabbit polyclonal antibody detecting HDAC3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human HDAC3 (Met1-Gln376).

타겟

HD3, SMAP45, RPD3-2, Histone deacetylase 3, HDAC3

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15379

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone deacetylase 3 (HDAC3) is a ~48 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

1. Chini, CC. et al. (2010) The Journal of biological chemistry 285, 40830-7. PMID: 21030595

2. Pillai, VB. et al. (2011) Molecular and cellular biology 31, 2349-63. PMID: 21444723

3. Hatzi, K. et al. (2013) Cell reports 4, 578-88. PMID: 23911289

4. Yi, J. et al. (2014) The Journal of biological chemistry 289, 33878-86. PMID: 25301942

5. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758

6. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

7. Zhan, W. et al. (2020) Oncogenesis 9, 48. PMID: 32404892

8. Watson, PJ. et al. (2012) Nature 481, 335-40. PMID: 22230954

10. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-HDAC3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-HDAC3 Polyclonal Antibody (HT281014)

개요

이미지

참고 문헌

데이터시트

SDS

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