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| 카탈로그 번호 | VK454013 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421) [SAA1421] (VK454013) is a alpaca monoclonal antibody detecting SOR protein in ELISA, IP.
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| 종 반응성 | Human immunodeficiency virus type 1 (HIV-1) | ||||
| 응용 분야 | ELISA, IP | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-8His-Cys-tag | ||||
| 클론 ID | SAA1421 | ||||
| 타겟 | Virion infectivity factor, Vif, SOR protein, p17, p7, vif | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | P12504 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Virion infectivity factor (Vif/SOR protein) is a ~22 kDa protein. Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G by promoting their ubiquitination and degradation. Acts as a substrate recognition component of an E3 ubiquitin-protein ligase complex: mechanistically, Vif hijacks a host cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) and the transcription coactivator CBFB/CBF-beta to form an active E3 ubiquitin-protein ligase complex that targets APOBEC3G and APOBEC3F for polyubiquitination, leading to their degradation by the proteasome. The complex can also ubiquitinate host APOBEC3H to some extent. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-HIV-1 Vif/SOR protein Nanobody (SAA1421)
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