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| 카탈로그 번호 | HW500014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human HK2 (Trp619-Arg917). | ||||||||
| 타겟 | HK II, Hexokinase type II, Hexokinase-2, Hexokinase-B, HK2, Muscle form hexokinase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P52789 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Hexokinase-2 (HK2) is a ~102 kDa protein. Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. 1. Cheung, EC. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20491-6. PMID: 23185017 2. Lin, H. et al. (2016) ACS medicinal chemistry letters 7, 217-22. PMID: 26985301 3. Nawaz, MH. et al. (2018) Bioscience reports 38. PMID: 29298880 4. Chiara, F. et al. (2008) PloS one 3, e1852. PMID: 18350175 | ||||||||
| 참고사항 | For research use only. |
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