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| 카탈로그 번호 | VK449024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HPV B19 VP1/Coat protein VP1 Polyclonal Antibody (VK449024) is a rabbit polyclonal antibody detecting VP1 in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Human parvovirus B19 | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human parvovirus B19 (HPV B19) VP1/Coat protein VP1 (His80-Ser227). | ||||||||
| 타겟 | capsid protein 1, VP1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P07299, Q9PZT0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Minor capsid protein VP1 (Coat protein VP1) is a ~86 kDa protein. Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 20 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Binds to erythroid progenitor cells expressing high levels of P antigen and uses host ITGA5-ITGB1 and XRCC5/Ku80 autoantigen as coreceptors on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. | ||||||||
| 참고사항 | For research use only. |
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