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| 카탈로그 번호 | VK412014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HPV52 E6/Protein E6 Polyclonal Antibody (VK412014) is a rabbit polyclonal antibody detecting Protein E6 in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Human papillomavirus 52 (HPV52) | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant HPV52 E6/Protein E6 (Met1-Val148). | ||||||||
| 타겟 | Protein E6, E6 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P36814 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein E6 is a ~17 kDa protein. Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). | ||||||||
| 참고사항 | For research use only. |
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