Anti-HSD11B2 Polyclonal Antibody (HX900014)

Name: Anti-HSD11B2 Polyclonal Antibody
Brand: abinScience
SKU: HX900014
Price: 168 USD
Availability: InStock

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100ug

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HX900014

설명

Anti-HSD11B2 Polyclonal Antibody (HX900014) is a rabbit polyclonal antibody detecting HSD11B2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human HSD11B2 (Gly106-Arg405).

타겟

HSD11B2, 11-beta-HSD type II, 11-beta-HSD, 11-DH2, Short chain dehydrogenase/reductase family 9C member 3, Corticosteroid 11-beta-dehydrogenase isozyme 2, SDR9C3, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, 11-beta-hydroxysteroid dehydrogenase type II, 11-beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, HSD11K, 11-HSD type II

정제

Purified by antigen affinity column.

등록번호

P80365

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) is a ~44 kDa protein. Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone.

1. Odermatt, A. et al. (1999) The Journal of biological chemistry 274, 28762-70. PMID: 10497248

2. Carvajal, CA. et al. (2003) The Journal of clinical endocrinology and metabolism 88, 2501-7. PMID: 12788846

3. Atanasov, AG. et al. (2007) Journal of the American Society of Nephrology : JASN 18, 1262-70. PMID: 17314322

4. Meyer, A. et al. (2012) Toxicology 301, 72-8. PMID: 22796344

5. Tsachaki, M. et al. (2017) The Journal of endocrinology 232, 323-335. PMID: 27927697

6. Beck, KR. et al. (2019) The Journal of steroid biochemistry and molecular biology 190, 19-28. PMID: 30902677

7. Inderbinen, SG. et al. (2021) Toxicology and applied pharmacology 412, 115387. PMID: 33387577

8. Albiston, AL. et al. (1994) Molecular and cellular endocrinology 105, R11-7. PMID: 7859916

9. Stewart, PM. et al. (1996) Lancet (London, England) 347, 88-91. PMID: 8538347

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-HSD11B2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-HSD11B2 Polyclonal Antibody (HX900014)

개요

이미지

참고 문헌

데이터시트

SDS