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| 카탈로그 번호 | HW649014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HSPA1L Polyclonal Antibody (HW649014) is a rabbit polyclonal antibody detecting HSPA1L in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Bos mutus grunniens.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human HSPA1L (Met1-Asp641). | ||||||||
| 타겟 | HSP70-Hom, Heat shock 70 kDa protein 1L, Heat shock 70 kDa protein 1-like, HSPA1L, Heat shock 70 kDa protein 1-Hom | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P34931 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Heat shock 70 kDa protein 1-like (HSPA1L) is a ~70 kDa protein. Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. 1. Radons, J. (2016) Cell stress & chaperones 21, 379-404. PMID: 26865365 2. Hasson, SA. et al. (2013) Nature 504, 291-5. PMID: 24270810 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-HSPA1L polyclonal antibody at 1μg/ml on various samples.
Lane 1: PC12 cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Human plasma lysate
Lane 4: Mouse spleen lysate
Lane 5: Mouse liver lysate
Lane 6: Mouse kidney lysate
Lane 7: Mouse lung lysate
Lane 8: Rat spleen lysate
Lane 9: Rat liver lysate
Lane 10: Rat kidney lysate
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