Anti-HSV1/HHV-1 ICP0 Polyclonal Antibody (VK083014)

Name: Anti-HSV1/HHV-1 ICP0 Polyclonal Antibody
Brand: abinScience
SKU: VK083014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

VK083014

설명

Anti-HSV1/HHV-1 ICP0 Polyclonal Antibody (VK083014) is a rabbit polyclonal antibody detecting ICP0 in ELISA, IHC, WB. Suitable for Human herpesvirus 1.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1) (HSV-1)

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant hsv1/hhv-1 ICP0 (Leu639-Ser762).

타겟

E3 ubiquitin-protein ligase ICP0, EC:2.3.2.27, Alpha-0 protein, Immediate-early protein IE110, RING-type E3 ubiquitin transferase ICP0, Trans-acting transcriptional protein ICP0, VMW110, ICP0

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P08393

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase ICP0 is a ~78 kDa protein. SUMO-targeted ubiquitin ligase that plays an essential role in nuclear antiviral defense evasion triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML, SP100, MORC2 and MORC3. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells.

1. Hembram, DSS. et al. (2020) Journal of molecular biology 432, 1952-1977. PMID: 32001251

2. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897

3. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314

4. Roubille, S. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2412258121. PMID: 39589886

참고사항

For research use only

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참고 문헌

데이터시트

Anti-HSV1/HHV-1 ICP0 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-HSV1/HHV-1 ICP0 Polyclonal Antibody (VK083014)

개요

이미지

참고 문헌

데이터시트

SDS