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| 카탈로그 번호 | MY581014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HTR1A Polyclonal Antibody (MY581014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; Gpcr18 in ELISA, IHC, WB. Suitable for Mouse and Rat.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant mouse HTR1A (Ile218-Lys345). | ||||||||
| 타겟 | 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; Gpcr18 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q64264, P19327 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | 5-hydroxytryptamine receptor 1A (HTR1A) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. 1. Ase, AR. et al. (2000) Journal of neurochemistry 75, 2415-26. PMID: 11080193 2. Deng, DR. et al. (2007) Neuroscience 147, 388-402. PMID: 17543467 3. Audero, E. et al. (2008) Science (New York, N.Y.) 321, 130-3. PMID: 18599790 4. Richardson-Jones, JW. et al. (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 6008-18. PMID: 21508226 5. Charest, A. et al. (1993) The Journal of neuroscience : the official journal of the Society for Neuroscience 13, 5164-71. PMID: 8254366 6. Ramboz, S. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 14476-81. PMID: 9826725 | ||||||||
| 참고사항 | For research use only. |
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