Anti-Human ABCC5 Polyclonal Antibody (HT488014)

Name: Anti-Human ABCC5 Polyclonal Antibody
Brand: abinScience
SKU: HT488014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT488014

설명

Anti-Human ABCC5 Polyclonal Antibody (HT488014) is a rabbit polyclonal antibody detecting ABCC5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ABCC5 (Ala629-Gly847).

타겟

ATP-binding cassette sub-family C member 5, 7.6.2.-, 7.6.2.2, Multi-specific organic anion transporter C, MOAT-C, Multidrug resistance-associated protein 5, SMRP, pABC11, ABCC5, MRP5

정제

Purified by antigen affinity column.

등록번호

O15440

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

ATP-binding cassette sub-family C member 5 (ABCC5) is a ~160 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated.

1. Jedlitschky, G. et al. (2000) The Journal of biological chemistry 275, 30069-74. PMID: 10893247

2. Wielinga, PR. et al. (2003) The Journal of biological chemistry 278, 17664-71. PMID: 12637526

3. Reid, G. et al. (2003) Molecular pharmacology 63, 1094-103. PMID: 12695538

4. Wielinga, P. et al. (2005) Cancer research 65, 4425-30. PMID: 15899835

5. de Wolf, CJ. et al. (2007) The FEBS journal 274, 439-50. PMID: 17229149

6. Jansen, RS. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 6601-6. PMID: 25964343

7. Jansen, RS. et al. (2015) The Journal of biological chemistry 290, 30429-40. PMID: 26515061

8. Wijnholds, J. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 7476-81. PMID: 10840050

9. Wielinga, PR. et al. (2002) Molecular pharmacology 62, 1321-31. PMID: 12435799

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human ABCC5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human ABCC5 Polyclonal Antibody (HT488014)

개요

이미지

참고 문헌

데이터시트

SDS

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