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| 카탈로그 번호 | HW543014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ACADSB (Thr58-Tyr432). | ||||||||
| 타겟 | 2-methyl branched chain acyl-CoA dehydrogenase, SBCAD, 2-MEBCAD, 2-methylbutyryl-CoA dehydrogenase, ACADSB, Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial, 2-methylbutyryl-coenzyme A dehydrogenase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P45954 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) is a ~47 kDa protein. Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug. 1. Gibson, KM. et al. (2000) Pediatric research 47, 830-3. PMID: 10832746 2. Andresen, BS. et al. (2000) American journal of human genetics 67, 1095-103. PMID: 11013134 3. Luís, PB. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 1155-60. PMID: 21430231 4. Rozen, R. et al. (1994) Genomics 24, 280-7. PMID: 7698750 | ||||||||
| 참고사항 | For research use only. |
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