Anti-Human ACTR3 Polyclonal Antibody (HX211014)

Name: Anti-Human ACTR3 Polyclonal Antibody
Brand: abinScience
SKU: HX211014
Price: 96 USD
Availability: InStock

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HX211014

설명

Anti-Human ACTR3 Polyclonal Antibody (HX211014) is a rabbit polyclonal antibody detecting ACTR3 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Human, Xenopus laevis, and Takifugu rubripes.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ACTR3 (Pro6-Lys254).

타겟

ACTR3

정제

Purified by antigen affinity column.

등록번호

P61158

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Actin-related protein 3, Actin-like protein 3, ACTR3, ARP3

배경

Actin-related protein 3 (ACTR3) is a ~47 kDa protein. ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.

1. Welch, MD. et al. (1997) Nature 385, 265-9. PMID: 9000076

2. Rao, J. et al. (2017) The Journal of clinical investigation 127, 4257-4269. PMID: 29058690

3. Yoo, Y. et al. (2007) The Journal of biological chemistry 282, 7616-23. PMID: 17220302

4. Schrank, BR. et al. (2018) Nature 559, 61-66. PMID: 29925947

5. Kim, J. et al. (2010) Nature 464, 1048-51. PMID: 20393563

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-ACTR3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: A549 cell lysate
Lane 2: A431 cell lysate
Lane 3: HL60 cell lysate
Lane 4: Hela cell lysate
Lane 5: Jurkat cell lysate
Lane 6: K562 cell lysate
Lane 7: PC-3 cell lysate
Lane 8: U2OS cell lysate
Lane 9: Mouse spleen lysate
Lane 10: Mouse lung lysate
Lane11: Mouse liver lysate
Lane12: Rat spleen lysate
Lane13: Rat lung lysate
Lane14: Rat liver lysate

참고 문헌

데이터시트

Anti-Human ACTR3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human ACTR3 Polyclonal Antibody (HX211014)

개요

이미지

참고 문헌

데이터시트

SDS

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