Anti-Human PAC1R Recombinant Antibody (SAA0130), FITC (HW609117)

Name: Anti-Human PAC1R Recombinant Antibody (SAA0130), FITC
Brand: abinScience
SKU: HW609117
Price: 223 USD
Availability: InStock

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개요
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개요

카탈로그 번호	HW609117
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	SAA0130
접합	FITC
타겟	ADCYAP1R1, PACAP-R-1, PACAP type I receptor, Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP-R1
내독소 수준	< 10 EU/mg
순도	>90% as determined by SDS-PAGE.
관련 제품	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
등록번호	P41586
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. 1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378 3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

이미지

Flow CytoMetry

Flow-cytometry using FITC anti-human ADCYAP1R1 antibody. SH-SY5Y cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human ADCYAP1R1 monoclonal antibody (Catalog: HW609117, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

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