Anti-Human PAC1R Recombinant Antibody (SAA0130) (HW609107)

Name: Anti-Human PAC1R Recombinant Antibody (SAA0130)
Brand: abinScience
SKU: HW609107
Price: 191 USD
Availability: InStock

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HW609107
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	SAA0130
타겟	ADCYAP1R1, PACAP-R-1, PACAP type I receptor, Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP-R1
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P41586
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. 1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378 3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
참고사항	For research use only.

이미지

Flow Cytometry

Flow-cytometry using anti-human ADCYAD1R1 antibody. Human SH-SY5Y cell line were stained with an irrelevant antibody (Green Histogram) or an anti-human ADCYAD1R1 antibody monoclonal antibody (Catalog # HW609107 , Red Histogram) at a concentration of 20 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Anti-Human ADCYAP1R1 Antibody (SAA0130)