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| 카탈로그 번호 | HB002013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1577 | ||||
| 타겟 | Beta-3 adrenoreceptor, Beta-3 adrenoceptor, B3AR, ADRB3, Beta-3 adrenergic receptor, ADRB3R | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P13945 | ||||
| RRID | Anti-Human ADRB3 Antibody (SAA1577) (abinScience Cat# HB002013, RRID:AB_3727338) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Beta-3 adrenergic receptor (ADRB3) is a ~43 kDa protein. G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. 1. Igawa, Y. et al. (1999) British journal of pharmacology 126, 819-25. PMID: 10188996 2. Emorine, LJ. et al. (1989) Science (New York, N.Y.) 245, 1118-21. PMID: 2570461 3. Candelore, MR. et al. (1996) Endocrinology 137, 2638-41. PMID: 8641219 4. Soeder, KJ. et al. (1999) The Journal of biological chemistry 274, 12017-22. PMID: 10207024 5. Gauthier, C. et al. (1998) The Journal of clinical investigation 102, 1377-84. PMID: 9769330 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human ADRB3 Antibody (SAA1577)
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