Anti-Human AKAP8 Polyclonal Antibody (HT110014)

Name: Anti-Human AKAP8 Polyclonal Antibody
Brand: abinScience
SKU: HT110014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HT110014

설명

Anti-Human AKAP8 Polyclonal Antibody (HT110014) is a rabbit polyclonal antibody detecting AKAP8 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human AKAP8 (Met1-Glu572).

타겟

AKAP8, A-kinase anchor protein 8, AKAP95, AKAP-8, A-kinase anchor protein 95 kDa, AKAP 95

정제

Purified by antigen affinity column.

등록번호

O43823

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

A-kinase anchor protein 8 (AKAP8) is a ~76 kDa protein. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis.

1. Eide, T. et al. (1998) Experimental cell research 238, 305-16. PMID: 9473338

2. Collas, P. et al. (1999) The Journal of cell biology 147, 1167-80. PMID: 10601332

3. Steen, RL. et al. (2000) The Journal of cell biology 149, 531-6. PMID: 10791967

4. Eide, T. et al. (2002) EMBO reports 3, 426-32. PMID: 11964380

5. Arsenijevic, T. et al. (2004) The Biochemical journal 378, 673-9. PMID: 14641107

6. Li, Y. et al. (2006) Genes & development 20, 2566-79. PMID: 16980585

7. Gao, X. et al. (2012) Molecular biology of the cell 23, 503-15. PMID: 22130794

8. Eide, T. et al. (2003) The Journal of biological chemistry 278, 26750-6. PMID: 12740381

9. Jiang, H. et al. (2013) Nature structural & molecular biology 20, 1156-63. PMID: 23995757

10. Kamada, S. et al. (2005) Molecular and cellular biology 25, 9469-77. PMID: 16227597

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human AKAP8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human AKAP8 Polyclonal Antibody (HT110014)

개요

이미지

참고 문헌

데이터시트

SDS

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