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| 카탈로그 번호 | HP973014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ALKBH7 (Ser16-Cys221). | ||||||||
| 타겟 | Spermatogenesis-associated protein 11, ABH7, Alkylated DNA repair protein alkB homolog 7, ALKBH7, Spermatogenesis cell proliferation-related protein, SPATA11, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9BT30 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | RNA demethylase ALKBH7, mitochondrial is a ~24 kDa protein. RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism. 1. Zhang, LS. et al. (2021) Nature cell biology 23, 684-691. PMID: 34253897 2. Fu, D. et al. (2013) Genes & development 27, 1089-100. PMID: 23666923 | ||||||||
| 참고사항 | For research use only. |
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