中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HA840013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | SAA2123 | ||||
| 타겟 | ANAPC2, anaphase promoting complex subunit 2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9UJX6 | ||||
| RRID | Anti-Human ANAPC2 Antibody (SAA2123) (abinScience Cat# HA840013, RRID:AB_3729475) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Anaphase-promoting complex subunit 2 (ANAPC2) is a ~93 kDa protein. Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. 1. Tang, Z. et al. (2001) Molecular biology of the cell 12, 3839-51. PMID: 11739784 2. Jin, L. et al. (2008) Cell 133, 653-65. PMID: 18485873 3. Yau, RG. et al. (2017) Cell 171, 918-933.e20. PMID: 29033132 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human ANAPC2 Antibody (SAA2123)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
