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| 카탈로그 번호 | HP196014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ANKRD27 (Met654-Ser902). | ||||||||
| 타겟 | ANKRD27, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96NW4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ankyrin repeat domain-containing protein 27 (ANKRD27) is a ~116 kDa protein. May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. 1. Zhang, X. et al. (2006) Journal of cell science 119, 1053-62. PMID: 16525121 2. Wang, F. et al. (2008) Biochemical and biophysical research communications 372, 162-7. PMID: 18477474 3. Schäfer, IB. et al. (2012) Nature structural & molecular biology 19, 1300-9. PMID: 23104059 4. Burgo, A. et al. (2012) Developmental cell 23, 166-80. PMID: 22705394 5. Burgo, A. et al. (2009) EMBO reports 10, 1117-24. PMID: 19745841 6. Hesketh, GG. et al. (2014) Developmental cell 29, 591-606. PMID: 24856514 | ||||||||
| 참고사항 | For research use only. |
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