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| 카탈로그 번호 | HY297023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA2551 | ||||
| 타겟 | ANX2, ANX2L4, ANXA2, Annexin A2, Annexin II, Annexin-2, CAL1H, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, LPC2D, Lipocortin II, PAP-IV, Placental anticoagulant protein IV, Protein I, p36 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P07355 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Annexin A2 (ANXA2) is a ~38 kDa protein. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. 1. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 2. Seidah, NG. et al. (2012) PloS one 7, e41865. PMID: 22848640 3. Ly, K. et al. (2014) The Journal of biological chemistry 289, 17732-46. PMID: 24808179 | ||||
| 참고사항 | For research use only | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human ANXA2 Antibody (SAA2551)
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