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| 카탈로그 번호 | HT287014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ARPC3 (Asp40-Gln178). | ||||||||
| 타겟 | Arp2/3 complex 21 kDa subunit, p21-ARC, ARPC3, Actin-related protein 2/3 complex subunit 3, ARC21 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O15145 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Actin-related protein 2/3 complex subunit 3 (ARPC3) is a ~20 kDa protein. Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). 1. Welch, MD. et al. (1997) The Journal of cell biology 138, 375-84. PMID: 9230079 2. Schrank, BR. et al. (2018) Nature 559, 61-66. PMID: 29925947 | ||||||||
| 참고사항 | For research use only. |
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