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| 카탈로그 번호 | HB098014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ATF2 Polyclonal Antibody (HB098014) is a rabbit polyclonal antibody detecting ATF2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ATF2 (Lys2-Met107). | ||||||||
| 타겟 | ATF2, cAMP response element-binding protein CRE-BP1, CREB2, CREBP1, cAMP-responsive element-binding protein 2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, HB16, Cyclic AMP-dependent transcription factor ATF-2, CREB-2, Cyclic AMP-responsive element-binding protein 2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P15336 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cyclic AMP-dependent transcription factor ATF-2 (ATF2) is a ~54 kDa protein. Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). 1. Kawasaki, H. et al. (2000) Nature 405, 195-200. PMID: 10821277 | ||||||||
| 참고사항 | For research use only. |
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