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| 카탈로그 번호 | HP002014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ATP6V0A1 Polyclonal Antibody (HP002014) is a rabbit polyclonal antibody detecting ATP6V0A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ATP6V0A1 (Arg167-Arg241). | ||||||||
| 타겟 | V-ATPase 116 kDa subunit a1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1, ATP6V0A1, V-type proton ATPase 116 kDa subunit a1, ATP6N1, Vacuolar proton pump subunit 1, VPP1, Vacuolar adenosine triphosphatase subunit Ac116, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, ATP6N1A | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q93050 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) is a ~96 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment. Required for assembly and activity of the vacuolar ATPase. Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons. 1. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002 2. Aoto, K. et al. (2021) Nature communications 12, 2107. PMID: 33833240 3. Bott, LC. et al. (2021) Brain communications 3, fcab245. PMID: 34909687 | ||||||||
| 참고사항 | For research use only. |
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