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| 카탈로그 번호 | HC586013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1672 | ||||
| 타겟 | FRP1, Serine/threonine-protein kinase ATR, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q13535 | ||||
| RRID | Anti-Human ATR Antibody (SAA1672) (abinScience Cat# HC586013, RRID:AB_3727433) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Serine/threonine-protein kinase ATR is a ~301 kDa protein. Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. 1. Hall-Jackson, CA. et al. (1999) Oncogene 18, 6707-13. PMID: 10597277 2. Kim, ST. et al. (1999) The Journal of biological chemistry 274, 37538-43. PMID: 10608806 3. Liu, Q. et al. (2000) Genes & development 14, 1448-59. PMID: 10859164 4. Cortez, D. et al. (2001) Science (New York, N.Y.) 294, 1713-6. PMID: 11721054 5. Zou, L. et al. (2003) Science (New York, N.Y.) 300, 1542-8. PMID: 12791985 6. Barr, SM. et al. (2003) Current biology : CB 13, 1047-51. PMID: 12814551 7. Wang, Y. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 15387-92. PMID: 14657349 8. Unsal-Kaçmaz, K. et al. (2004) Molecular and cellular biology 24, 1292-300. PMID: 14729973 9. Ward, IM. et al. (2004) The Journal of biological chemistry 279, 9677-80. PMID: 14742437 10. Cortez, D. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 10078-83. PMID: 15210935 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human ATR Antibody (SAA1672)
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