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| 카탈로그 번호 | HC152015 |
|---|---|
| 설명 |
Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) [1A571] (HC152015) is a mouse monoclonal antibody detecting ATRX in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, IHC, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | 1A571 |
| 면역원 | E. coli - derived recombinant human ATRX/RAD54L (Thr1534-Asp1916). |
| 타겟 | Transcriptional regulator ATRX, EC:3.6.4.12, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P46100 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Transcriptional regulator ATRX (RAD54L) is a ~282 kDa protein. Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. 1. Episkopou, H. et al. (2014) Nucleic acids research 42, 4391-405. PMID: 24500201 2. Valle-García, D. et al. (2016) Epigenetics 11, 398-414. PMID: 27029610 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571)
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