Anti-Human AUP1 Polyclonal Antibody (HV444014)

Name: Anti-Human AUP1 Polyclonal Antibody
Brand: abinScience
SKU: HV444014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HV444014

설명

Anti-Human AUP1 Polyclonal Antibody (HV444014) is a rabbit polyclonal antibody detecting AUP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human AUP1 (Val201-Asp410).

타겟

AUP1

정제

Purified by antigen affinity column.

등록번호

Q9Y679

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Lipid droplet-regulating VLDL assembly factor AUP1, Ancient ubiquitous protein 1, AUP1

배경

Lipid droplet-regulating VLDL assembly factor AUP1 is a ~45 kDa protein. Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2.

1. Mueller, B. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12325-30. PMID: 18711132

2. Klemm, EJ. et al. (2011) The Journal of biological chemistry 286, 37602-14. PMID: 21857022

3. Lohmann, D. et al. (2013) PloS one 8, e72453. PMID: 24039768

4. Spandl, J. et al. (2011) The Journal of biological chemistry 286, 5599-606. PMID: 21127063

5. Jo, Y. et al. (2013) Molecular biology of the cell 24, 169-83. PMID: 23223569

6. Zhang, J. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 633-642. PMID: 28183703

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human AUP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human AUP1 Polyclonal Antibody (HV444014)

개요

이미지

참고 문헌

데이터시트

SDS