Anti-Human Axl Polyclonal Antibody (HB709024)

Name: Anti-Human Axl Polyclonal Antibody
Brand: abinScience
SKU: HB709024
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HB709024

설명

Anti-Human AXL/UFO Polyclonal Antibody (HB709024) is a rabbit polyclonal antibody detecting AXL. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human AXL/UFO (Gly545-Leu810).

타겟

AXL, AXL oncogene, EC:2.7.10.1, Tyrosine-protein kinase receptor UFO, UFO

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P30530

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.

참고사항

For research use only

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