Anti-Human BACE2 Polyclonal Antibody (HV256014)

Name: Anti-Human BACE2 Polyclonal Antibody
Brand: abinScience
SKU: HV256014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HV256014

설명

Anti-Human BACE2 Polyclonal Antibody (HV256014) is a rabbit polyclonal antibody detecting BACE2. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human BACE2 (Phe77-Ser445).

타겟

AEPLC, ALP56, ASP1, ASP21, Asp 1, Aspartic-like protease 56 kDa, Aspartyl protease 1, BACE2, Beta-secretase 2, Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, DRAP, Down region aspartic protease, EC:3.4.23.45, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q9Y5Z0

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.

1. Yan, R. et al. (1999) Nature 402, 533-7. PMID: 10591213

2. Hussain, I. et al. (2000) Molecular and cellular neurosciences 16, 609-19. PMID: 11083922

3. Yan, R. et al. (2001) The Journal of biological chemistry 276, 34019-27. PMID: 11423558

4. Sun, X. et al. (2005) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 739-49. PMID: 15857888

5. Sun, X. et al. (2006) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 1369-76. PMID: 16816112

6. Rochin, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10658-63. PMID: 23754390

7. Esterházy, D. et al. (2011) Cell metabolism 14, 365-77. PMID: 21907142

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human BACE2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human BACE2 Polyclonal Antibody (HV256014)

개요

이미지

참고 문헌

데이터시트

SDS