Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

Name: Anti-Human BAG3 Recombinant Antibody (SAA0529), APC
Brand: abinScience
SKU: HF640137
Price: 214 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호	HF640137
종 반응성	Human
응용 분야	ELISA, FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2a, kappa
클론 ID	SAA0529
접합	APC
타겟	Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
내독소 수준	Please contact with the lab for this information.
등록번호	O95817
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). 1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606 2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338 3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739 4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016 5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216 6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human BAG3 Recombinant Antibody (SAA0529), APC.pdf

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Formula

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Anti-Human BAG3 Recombinant Antibody (SAA0529), APC (HF640137)

개요

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참고 문헌

데이터시트

SDS

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