Anti-Human BAX Recombinant Nanobody (SAA2133) (HC491053)

Name: Anti-Human BAX Recombinant Nanobody (SAA2133)
Brand: abinScience
SKU: HC491053
Price: 126 USD
Availability: InStock

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사양:

20ug
50ug
100ug
1mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC491053

설명

Anti-Human BAX Nanobody (SAA2133) [SAA2133] (HC491053) is a alpaca monoclonal antibody detecting BAX in ELISA, SPR. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, SPR

숙주 종

Alpaca

클론성

Monoclonal

이소타입

VHH-8His-Cys-tag

클론 ID

SAA2133

타겟

BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by Nickel column.

등록번호

Q07812

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Apoptosis regulator BAX is a ~21 kDa protein. Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

1. Schmitt, E. et al. (2000) Biochemical and biophysical research communications 270, 868-79. PMID: 10772918

2. Tan, KO. et al. (2001) The Journal of biological chemistry 276, 2802-7. PMID: 11060313

3. Zhang, H. et al. (2005) Nature cell biology 7, 909-15. PMID: 16113678

4. Tan, KO. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 14623-8. PMID: 16199525

5. Gavathiotis, E. et al. (2008) Nature 455, 1076-81. PMID: 18948948

6. Czabotar, PE. et al. (2011) The Journal of biological chemistry 286, 7123-31. PMID: 21199865

7. Edlich, F. et al. (2011) Cell 145, 104-16. PMID: 21458670

8. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812

9. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894

10. Oltvai, ZN. et al. (1993) Cell 74, 609-19. PMID: 8358790

참고사항

For research use only.

이미지

SDS-PAGE

SDS-PAGE for Anti-Human BAX Nanobody (SAA2133).

참고 문헌

데이터시트

Anti-Human BAX Recombinant Nanobody (SAA2133).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human BAX Recombinant Nanobody (SAA2133) (HC491053)

개요

이미지

참고 문헌

데이터시트

SDS

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