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| 카탈로그 번호 | HA499014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human BAZ1A Polyclonal Antibody (HA499014) is a rabbit polyclonal antibody detecting BAZ1A in ELISA, IHC, WB. Suitable for Mus musculus and Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BAZ1A (Leu549-Arg666). | ||||||||
| 타겟 | BAZ1A | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9NRL2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 대체 이름 | Bromodomain adjacent to zinc finger domain protein 1A, ATP-dependent chromatin-remodeling protein, ATP-utilizing chromatin assembly and remodeling factor 1, hACF1, CHRAC subunit ACF1, Williams syndrome transcription factor-related chromatin-remodeling factor 180, WCRF180, hWALp1, BAZ1A, ACF1, WCRF180, HSPC317 | ||||||||
| 배경 | Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) is a ~178 kDa protein. Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. 1. Yang, JG. et al. (2006) Nature structural & molecular biology 13, 1078-83. PMID: 17099699 2. Oppikofer, M. et al. (2017) EMBO reports 18, 1697-1706. PMID: 28801535 3. Kukimoto, I. et al. (2004) Molecular cell 13, 265-77. PMID: 14759371 4. Collins, N. et al. (2002) Nature genetics 32, 627-32. PMID: 12434153 5. Ewing, AK. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 1791-806. PMID: 17519354 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-BAZ1A polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
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