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| 카탈로그 번호 | HT430013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1499 | ||||
| 타겟 | AMPHL, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O00499 | ||||
| RRID | Anti-Human BIN1 Antibody (SAA1499) (abinScience Cat# HT430013, RRID:AB_3727260) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Myc box-dependent-interacting protein 1 (BIN1/Amphiphysin-II) is a ~64 kDa protein. Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. 1. Wu, T. et al. (2014) PloS one 9, e93060. PMID: 24755653 2. Miyagawa, T. et al. (2016) Human molecular genetics 25, 2948-2958. PMID: 27179792 3. Sakamuro, D. et al. (1996) Nature genetics 14, 69-77. PMID: 8782822 4. Dräger, NM. et al. (2017) EMBO reports 18, 2051-2066. PMID: 28893863 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human BIN1 Antibody (SAA1499)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
