Anti-Human BIRC6 Polyclonal Antibody (HV669014)

Name: Anti-Human BIRC6 Polyclonal Antibody
Brand: abinScience
SKU: HV669014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HV669014

설명

Anti-Human BIRC6 Polyclonal Antibody (HV669014) is a rabbit polyclonal antibody detecting BIRC6. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human BIRC6 (Arg4576-Leu4857).

타겟

APOLLON, BIR repeat-containing ubiquitin-conjugating enzyme, BIRC6, BRUCE, Baculoviral IAP repeat-containing protein 6, Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6, EC:2.3.2.24, KIAA1289, Ubiquitin-conjugating BIR domain enzyme apollon

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9NR09

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 is a ~530 kDa protein. Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent.

1. Qiu, XB. et al. (2004) The EMBO journal 23, 800-10. PMID: 14765125

2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957

3. Pohl, C. et al. (2008) Cell 132, 832-45. PMID: 18329369

4. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104

5. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105

6. Dietz, L. et al. (2023) Science (New York, N.Y.) 379, 1112-1117. PMID: 36758106

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human BIRC6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human BIRC6 Polyclonal Antibody (HV669014)

개요

이미지

참고 문헌

데이터시트

SDS