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| 카탈로그 번호 | HY077013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1793 | ||||
| 타겟 | PCOLC, Mammalian tolloid protein, mTld, Bone morphogenetic protein 1, PCP, BMP-1, Procollagen C-proteinase, BMP1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P13497 | ||||
| RRID | Anti-Human BMP1 Antibody (SAA1793) (abinScience Cat# HY077013, RRID:AB_3727555) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Bone morphogenetic protein 1 (BMP1) is a ~111 kDa protein. Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. 1. N'Diaye, EN. et al. (2021) American journal of physiology. Cell physiology 320, C162-C174. PMID: 33206546 2. Anastasi, C. et al. (2020) Science signaling 13. PMID: 32636307 3. Wang, J. et al. (2021) Journal of periodontology 92, 1018-1029. PMID: 33169406 4. Rosell-García, T. et al. (2019) The Journal of biological chemistry 294, 11087-11100. PMID: 31152061 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human BMP1 Antibody (SAA1793)
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