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| 카탈로그 번호 | HF006014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human BPNT1 Polyclonal Antibody (HF006014) is a rabbit polyclonal antibody detecting BPNT1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BPNT1 (Met1-Pro308). | ||||||||
| 타겟 | 3'(2'), 5'-bisphosphate nucleotidase 1, 3.1.3.7, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase, Bisphosphate 3'-nucleotidase 1, BPntase 1, HsPIP, Inositol-polyphosphate 1-phosphatase, 3.1.3.57, BPNT1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95861 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) is a ~33 kDa protein. Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate. Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate. 1. Yenush, L. et al. (2000) FEBS letters 467, 321-5. PMID: 10675562 | ||||||||
| 참고사항 | For research use only. |
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