Anti-Human BTLA/CD272 Polyclonal Antibody (HV375014)

Name: Anti-Human BTLA/CD272 Polyclonal Antibody
Brand: abinScience
SKU: HV375014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HV375014

설명

Anti-Human BTLA Polyclonal Antibody (HV375014) is a rabbit polyclonal antibody detecting B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human BTLA (Lys31-Ser150).

타겟

B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q7Z6A9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

B- and T-lymphocyte attenuator (BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776

2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006

3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026

4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050

5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044

참고사항

For research use only

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