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| 카탈로그 번호 | HY181013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1569 | ||||
| 타겟 | C7, Complement component C7 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P10643 | ||||
| RRID | Anti-Human C7 Antibody (SAA1569) (abinScience Cat# HY181013, RRID:AB_3727330) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Complement component C7 (Complement C7) is a ~93 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending. 1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 3. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 4. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 5. DiScipio, RG. et al. (1988) The Journal of biological chemistry 263, 549-60. PMID: 3335508 6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human C7 Antibody (SAA1569)
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