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| 카탈로그 번호 | HY173014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human C8A Polyclonal Antibody (HY173014) is a rabbit polyclonal antibody detecting C8A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human C8A (Ala135-Arg498). | ||||||||
| 타겟 | Complement component C8 alpha chain, Complement component 8 subunit alpha, C8A | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P07357 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Complement component C8 alpha chain (C8A) is a ~65 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8A, together with C8B and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity. 1. Hadders, MA. et al. (2007) Science (New York, N.Y.) 317, 1552-4. PMID: 17872444 2. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 3. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 6. Steckel, EW. et al. (1980) The Journal of biological chemistry 255, 11997-2005. PMID: 7440581 7. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 8. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 9. Steckel, EW. et al. (1983) The Journal of biological chemistry 258, 4318-24. PMID: 6833260 | ||||||||
| 참고사항 | For research use only. |
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