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| 카탈로그 번호 | HC588023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | IHC, IP, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | L57/46R | ||||
| 타겟 | Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1, Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Rat brain class C, RBC, Voltage-gated calcium channel subunit alpha Cav1.2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q13936 | ||||
| RRID | Anti-Human CACNA1C Antibody (L57/46R) (abinScience Cat# HC588023, RRID:AB_3726995) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. 1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 12181424 2. Splawski, I. et al. (2004) Cell 119, 19-31. PMID: 15454078 3. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 15863612 4. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 16299511 5. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 17224476 6. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 20953164 7. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 23677916 8. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 24728418 9. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 26253506 10. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CACNA1C Antibody (L57/46R)
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