Anti-Human CAMK2D Polyclonal Antibody (HC230014)

Name: Anti-Human CAMK2D Polyclonal Antibody
Brand: abinScience
SKU: HC230014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HC230014

설명

Anti-Human CAMK2D Polyclonal Antibody (HC230014) is a rabbit polyclonal antibody detecting CAMK2D. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CAMK2D (Thr8-Asn313).

타겟

CAMK2D, CAMKD, CaM kinase II subunit delta, CaMK-II subunit delta, Calcium/calmodulin-dependent protein kinase type II subunit delta, EC:2.7.11.17

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q13557

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) is a ~56 kDa protein. Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program.

1. Little, GH. et al. (2007) The Journal of biological chemistry 282, 7219-31. PMID: 17179159

2. Rose, AJ. et al. (2006) The Journal of physiology 574, 889-903. PMID: 16690701

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human CAMK2D Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CAMK2D Polyclonal Antibody (HC230014)

개요

이미지

참고 문헌

데이터시트

SDS