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| 카탈로그 번호 | HW555033 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human CASP3 Nanobody (VHH2) [VHH2] (HW555033) is a alpaca monoclonal antibody detecting CASP3 in ELISA. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-8His-Cys-tag | ||||
| 클론 ID | VHH2 | ||||
| 타겟 | Caspase-3, CPP-32, CPP32, CASP-3, SREBP cleavage activity 1, CASP3, Apopain, SCA-1, Cysteine protease CPP32, Protein Yama | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P42574 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Caspase-3 (CASP3) is a ~31 kDa protein. Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis. Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively). 1. Walsh, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12815-9. PMID: 18723680 2. Nakatsumi, H. et al. (2010) The Journal of biological chemistry 285, 25418-25. PMID: 20566630 3. Thomsen, ND. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 8477-82. PMID: 23650375 4. Peng, T. et al. (2022) Molecular cell 82, 1806-1820.e8. PMID: 35338844 5. Liu, Y. et al. (2022) mBio 13, e0069022. PMID: 35446120 6. Nicholson, DW. et al. (1995) Nature 376, 37-43. PMID: 7596430 10. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CASP3 Nanobody (VHH2)
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