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| 카탈로그 번호 | HS897014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CCDC93 (Asp20-Ser151). | ||||||||
| 타겟 | CCDC93, Coiled-coil domain-containing protein 93 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q567U6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Coiled-coil domain-containing protein 93 (CCDC93) is a ~73 kDa protein. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C. 1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566 2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129 3. Phillips-Krawczak, CA. et al. (2015) Molecular biology of the cell 26, 91-103. PMID: 25355947 4. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079 | ||||||||
| 참고사항 | For research use only. |
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