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| 카탈로그 번호 | HB032207 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Rabbit |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | H6 |
| 타겟 | Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P19320 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. 1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649 2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034 3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700 4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CD106/VCAM1 Antibody (H6)
+86-027-65523339
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