Anti-Human CD141/THBD Polyclonal Antibody (HY397014)

Name: Anti-Human CD141/THBD Polyclonal Antibody
Brand: abinScience
SKU: HY397014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HY397014

설명

Anti-Human CD141/THBD Polyclonal Antibody (HY397014) is a rabbit polyclonal antibody detecting CD141 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD141/THBD (Ala19-Asp486).

타겟

THBD, THRM, CD141, Thrombomodulin, Fetomodulin, TM

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

P07204

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Thrombomodulin (CD141/THBD) is a ~60 kDa protein. Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.

1. Fuentes-Prior, P. et al. (2000) Nature 404, 518-25. PMID: 10761923

2. Daly, C. et al. (2018) Scientific reports 8, 505. PMID: 29323190

3. Giri, H. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33836597

4. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524

5. Wu, C. et al. (2016) Journal of thrombosis and haemostasis : JTH 14, 366-74. PMID: 26663133

6. Abeyama, K. et al. (2005) The Journal of clinical investigation 115, 1267-74. PMID: 15841214

참고사항

For research use only.

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