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| 카탈로그 번호 | HW392107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | 1D9 |
| 타겟 | CCR2, CC-CKR-2, C-C chemokine receptor type 2, CCR-2, C-C CKR-2, MCP-1-R, CMKBR2, CD192, Monocyte chemoattractant protein 1 receptor |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P41597 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | C-C chemokine receptor type 2 (CD192/CCR2) is a ~41 kDa protein. Key functional receptor for CCL2 but can also bind CCL7, and CCL12. Also transduces signaling mediated by CCL13. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. 1. Tan, JHY. et al. (2013) The Journal of biological chemistry 288, 10024-10034. PMID: 23408426 2. Neehus, AL. et al. (2024) Cell 187, 390-408.e23. PMID: 38157855 3. Yamagami, S. et al. (1994) Biochemical and biophysical research communications 202, 1156-62. PMID: 8048929 4. Charo, IF. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 2752-6. PMID: 8146186 5. De Paula, VS. et al. (2013) Journal of molecular biology 425, 4479-95. PMID: 23938203 |
| 참고사항 | For research use only. |
SEC-HPLC detection for Anti-Human CD192/CCR2 Antibody (1D9).
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