Anti-Human IGF-I R/IGF1R Recombinant Antibody (SAA0072) (HY353107)

Name: Anti-Human IGF-I R/IGF1R Recombinant Antibody (SAA0072)
Brand: abinScience
SKU: HY353107
Price: 191 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HY353107
종 반응성	Human
응용 분야	ELISA, FCM, WB
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	SAA0072
테스트된 응용 분야	FCM
타겟	CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P08069
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	Insulin-like growth factor 1 receptor (CD221/IGF1R) is a ~154 kDa protein. Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
참고사항	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human CD221/IGF1R Antibody (ABS0059).
Flow Cytometry

Flow-cytometry using anti-human IGFIR antibody. A549 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human IGFIR monoclonal antibody (Catalog HY353107, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.