中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HV480137 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | 36H12 |
| 접합 | APC |
| 타겟 | HVEA, HVEM, Herpes virus entry mediator A, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2, HveA, TNFRSF14, CD270, TR2, Herpesvirus entry mediator A |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| 등록번호 | Q92956 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Tumor necrosis factor receptor superfamily member 14 (CD270/TNFRSF14) is a ~30 kDa protein. Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. 1. Tamada, K. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4105-10. PMID: 10754304 2. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 3. Šedý, JR. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 828-36. PMID: 23761635 4. Mauri, DN. et al. (1998) Immunity 8, 21-30. PMID: 9462508 5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 6. Hsu, H. et al. (1997) The Journal of biological chemistry 272, 13471-4. PMID: 9153189 7. Marsters, SA. et al. (1997) The Journal of biological chemistry 272, 14029-32. PMID: 9162022 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
